RAF Typhoon FGR4s have operated alongside France's air force in a coordinated attack targeting an subterranean weapons facility in Syrian territory operated by the Islamic State group (IS), per a report from the UK Ministry of Defence.
The location, identified by intelligence, was believed to be containing munitions and bombs, the statement said, and was situated in hills just north of the historic site of Palmyra in Syria's central region.
"The RAF jets employed precision-guided Paveway IV munitions to hit a several access tunnels leading to the site... initial indications suggest the objective was successfully hit," the MoD said.
There was no indication of any civilian impact in the strike conducted Saturday night and every plane involved returned safely, the defence officials confirmed.
The British jets were supported by a Voyager tanker plane.
IS - referred to as Daesh - established extremist governance over large swathes of both Syria and Iraq until 2019.
"This action demonstrates our UK leadership, and commitment to work closely with our partners, to stamp out any resurgence of IS and their harmful and extremist ideologies in the region," Britain's Defence Chief the Defence Secretary remarked.
RAF aircraft have carried out surveillance missions over Syrian airspace to "prevent any efforts to regroup" of Islamic State after its routing at the climactic battle in Baghuz in the year 2019, the ministry said.
"I extend gratitude to the personnel of British forces participating in this mission for their expertise and their valour," he said. "They were among numerous UK service members deployed over the festive period. This action, to remove militants who threaten our safety, shows how our armed forces are ready to step up, continuously, ensuring Britain's security domestically and influential overseas."
In December, the American forces carried out what it described as a "major assault" against Daesh sites in the country, after an attack resulted in the deaths of two US servicemembers and a civilian linguist in the Palmyra area.
The United Nations estimates Daesh still has between 5,000 and 7,000 combatants in Syria and Iraq.